Small Animal Imaging Unit
Location: Bioengineering Bldg, 2nd Floor
The Small Animal Imaging Unit of the Cell & Molecular Imaging Shared Resource is a collaborative effort between the Center for Biomedical Imaging and the Hollings Cancer Center. Please click here to visit the Center for Biomedical Imaging website. The Small Animal Imaging Unit provides state-of-the-art instrumentation enabling noninvasive anatomical, metabolic, and functional imaging. By leveraging HCC cancer research experience with the facility’s extensive expertise in imaging, this unit is able to monitor cellular events such as tumor progression and metastasis in living animals. In vivo fluorescence and bioluminescence imaging is also used to evaluate tumor metabolism and cell biology in response to genetic manipulations, pharmacologic agents, and cancer chemotherapy drugs. This unit has experience in in vivo imaging of brain, colon, lung, head and neck cancers as well as multiple other tumor types.
The Small Animal Imaging Unit is equipped with the following instruments:
- Bruker 7T Small-Bore MRI: The BioSpec 70/30 MRI scanner is a multipurpose system for high-resolution MR spectroscopy and imaging that operates at 7 Tesla with a warm bore diameter of 30 cm well suited for 2D and 3D high-resolution anatomical imaging, diffusion/diffusion tensor imaging, flow imaging, cardiac imaging, dynamic contrast imaging, functional MRI, chemical shift imaging, and localized spectroscopy. A small animal monitoring system allows collection of core temperature, ECG, breathing frequency, blood oxygen level, and pulse rate.
- PerkinElmer Maestro 2 In Vivo Fluorescence Imaging System: The Maestro 2 provides state-of-the-art fluorescence imaging of small animals and generates anatomical organ maps for co-localization. Features include a light-tight enclosure, configurable imaging area, tunable multispectral camera, heated imaging chamber, and spectral unmixing. A solid-state LCTF captures multispectral fluorescence images of small animals at multiple user-defined wavelengths between blue and near infrared.
- PerkinElmer Xenogen IVIS 200 In Vivo Bioluminescence Imaging System: The IVIS 200 is capable of imaging up to five animals at a time and provides limited 3-D depth information. The imaging system includes a heated specimen platform for the animals and a cooled back-thinned CCD camera to capture both visible light photographs and luminescent images. Images can be obtained in less than one minute.
- Siemens Inveon Micro-PET/CT: This dual-modality system acquires co-registered micro-CT and micro-PET images so that PET image data can be anatomically localized from micro-CT imaging data. The micro-CT unit has a 30-80 kVp x-ray source with a 9 cm x 6 cm maximum field of view. Ultra-high resolution images down to 15 μm of ex vivo specimens can be obtained. For micro-PET studies, 18F-FDG metabolic imaging is available. Images of one to several millimeters are achievable.
- Small Animal Imaging Suites: The small animal imaging facility in the Bioengineering Building contains dedicated small animal husbandry space and surgical suites. Other ancillary laboratory equipment includes biosafety hoods, centrifuges, incubators, and a UV/Vis/NIR spectrophotometer/plate reader.
|Microscope||Base Rate/Hr||HCC Rate/Hr||After Hours Rate/Hr|
|BRuker 7T Small-bore MRI||$200||$150||NA|
|Siemens Inveon Micro-PET||$200||$150||NA|
|Siemens Inveon Micro-CT||$100||$75||NA|
|Siemens Inveon Micro-PET/CT||$250||$187.50||NA|
|Xenogen IVIS 200||$100||$75||NA|
|PerkinElmer Maestro 2||$100||$75||NA|