MUSC Hollings Cancer Center

Lipidomics - Synthesis Unit

Co-Director, Synthesis Unit
Zdzislaw Szulc, PhD
Research Associate Professor, Biochemistry & Molecular Biology
Contact:
szulcz@musc.edu
843-792-0755

Location: Rooms 748 and 747B - Basic Science Building

Staff Scientist
Aiping Bai, PhD
Research Assistant Professor, Biochemistry & Molecular Biology
843-792-0755

The Lipidomics Synthesis Unit has 820ft2 of laboratory space dedicated to the synthesis of sphingolipids and analogs. This laboratory is fully equipped with two hoods for organic chemical synthesis. A separate room for radioactive synthesis set up with a special hood equipped with and a Bioscan TLC plate reader. The synthesis unit also has access to the NMR Facility at MUSC as well as a fully equipped tissue culture room and dedicated office space.

The Lipid Synthesis Unit provides:

  • Total synthesis of natural sphingolipids (4 isomers for each sphingolipid) from the chiral precursors
  • Design and synthesis of various inhibitors of sphingolipid metabolizing enzymes
  • Design and synthesis of organelle-targeted Cers and inhibitors of sphingolipid metabolizing enzymes
  • Design and synthesis of molecular tools for metabolic studies: radiolabeled, fluorescent, and 17C sphingolipids (containing an unnatural 17C-sphingoid backbone)
  • Design and synthesis of molecular tools for determination of enzymatic activities

Synthetic Development & Compound Classification

Synthetic development and compound classification are based on the recognition of key sphingolipid enzymes, see chemical structures.

Synthetic Publications & Patents

View synthetic publications and patents

Services and Pricing

The Lipidomics Synthesis Unit provides compounds for the collaborative research and compounds for services priced on a customized basis per project.  Please consult Dr. Szulc at szulcz@musc.edu regarding pricing for your project.

Lipidomics Synthesis Request Form

 
 
 

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