Lipidomics - Synthesis Unit
Aiping Bai, PhD
Research Assistant Professor, Biochemistry & Molecular Biology
The Lipidomics Synthesis Unit has 820ft2 of laboratory space dedicated to the synthesis of sphingolipids and analogs. This laboratory is fully equipped with two hoods for organic chemical synthesis. A separate room for radioactive synthesis set up with a special hood equipped with and a Bioscan TLC plate reader. The synthesis unit also has access to the NMR Facility at MUSC as well as a fully equipped tissue culture room and dedicated office space.
The Lipid Synthesis Unit provides:
- Total synthesis of natural sphingolipids (4 isomers for each sphingolipid) from the chiral precursors
- Design and synthesis of various inhibitors of sphingolipid metabolizing enzymes
- Design and synthesis of organelle-targeted Cers and inhibitors of sphingolipid metabolizing enzymes
- Design and synthesis of molecular tools for metabolic studies: radiolabeled, fluorescent, and 17C sphingolipids (containing an unnatural 17C-sphingoid backbone)
- Design and synthesis of molecular tools for determination of enzymatic activities
Synthetic Development & Compound Classification
Synthetic development and compound classification are based on the recognition of key sphingolipid enzymes, see chemical structures.
Synthetic Publications & Patents
Services and Pricing
The Lipidomics Synthesis Unit provides compounds for the collaborative research and compounds for services priced on a customized basis per project. Please consult Dr. Szulc at firstname.lastname@example.org regarding pricing for your project.