K12 Research Tracks
3 Research Tracks
A. Drug discovery/development with a focus on small molecule drug development
♦ The Scholars who select the Drug Discovery/Development track will focus on discovering unique agents and
pathways that will result in novel approaches to cancer therapy. Faculty mentors will work with Scholars to
develop data to drive the development of Phase I and II clinical trials and move compounds from bench to
bedside. Scholars will learn to analyze preliminary results, develop pharmacokinetic modeling, and evaluate
appropriate patient biomarkers. They will also receive training in the latest “omics” technologies.
B. Cancer immunotherapy including immunoglobulin, vaccine, and cellular therapies
♦ Working with the faculty in the Division of Hematology/Oncology, the immunology faculty mentors are implementing a growing
number of novel immunotherapy trials through a GMP-grade cellular therapy facility. The facility can produce
cellular products such as dendritic cells, antigen specific T-cells, gene transduced immune cells, and mesenchymal
cells. This represents an ideal training opportunity for Scholars who are preparing to develop clinical/translational
protocols that will utilize these technologies. Cancer immunotherapy track Scholars will also be trained to use the
Flow Cytometry & Cell Sorting resource for immune monitoring of patients enrolled on trials.
C. Population sciences driven by cancer epidemiology, health behavior research, and implementation science
♦ Population sciences are not only germane to translating bedside clinical insights into population or systems, but
increasingly, these scientists are contributing to cross cutting genetic and genomic questions that will be essential
to understanding the epidemiological, health behavioral and dissemination barriers of personalized medicine.
Scholars who select the population sciences track will identify determinants of cancer risk and cancer control and
translate these findings into cost effective, sustainable interventions. Scholars that elect the cancer population
sciences track will have research rotation options with faculty engaged in epidemiology, health behavior research,
community participatory research, health policy research, and implementation science.